Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19COVID-19에 대한 인간 면역 시스템(HIS) 인간화 마우스 모델(DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD)Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] SARS, 유전자 메커니즘, [키워드] Anti-viral B cell Blood candidate vaccine CD4 CD8 Cell clinical condition Cord blood COVID-19 COVID-19 research cytotoxic activity DRAGA mice Efficacy epithelial Express expressing functional granzyme B Hematopoietic stem cell Human human ACE2 receptor human antibodies Human immune system human lung-resident CD8 T cells humanized humanized mice IgG antibody immune immunopathological in vivo infused intra-alveolar lung lung immunopathology lung immunopathology. Lungs lymphocyte mechanism mice microthrombi mounted perforin promote Proteins replicating virus response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral secreted surrogate switching System T cell T cells Therapeutics unique upper respiratory airway Viral proteins [DOI] 10.1080/21645515.2022.2048622 PMC 바로가기 [Article Type] Article
Identification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19Article Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome anti-inflammatory cytokine CD4 CD8 Cell Cell-based therapy conserved Conserved T cell epitope Coronavirinae coronavirus coronavirus Coronavirus disease 2019 Coverage COVID-19 COVID-19 in patients current epitope global public health help highlight Human identification Immunity infect Infection Inflammatory monoclonal antibody mutant new SARS-CoV-2 omicron outbreak pandemic PROTECT Protein RdRP restrict RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants secreted Seven specificity T cell T cells targeted epitope TCR TCR-T therapy. therapy transducing Treatment unique Vaccine variant variants [DOI] 10.1016/j.intimp.2022.109283 PMC 바로가기
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors receptors. regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19Review article Published on 2022-10-012022-10-05 Journal: Life sciences [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 acute respiratory syndrome alteration angiotensin-converting enzyme 2 Biomarker caused changes in Coagulation coagulation cascade coagulation factor Coagulation parameters Coagulopathy coronavirus Coronaviruses COVID-19 Cytochrome P450 enzymes cytokine Effect elevated Endothelial dysfunction enzyme In-hospital Infection Inflammation involved mechanism melatonin Mortality outcomes Patient Platelet Prophylactic RAS regulate reported risk factor SARS-CoV-2 SARS-COV-2 infection secreted severity Stress suggested the cytokine storm [DOI] 10.1016/j.lfs.2022.120866 [Article Type] Review article
Effect of Coronavirus Disease (COVID-19) on Human Semen: No Evidence of Coronavirus in Semen of PatientsArticle Published on 2022-09-122022-11-15 Journal: BioMed Research International [Category] SARS, 치료기술, [키워드] acute respiratory syndrome addition Analysis analyzed Blood both group China clinical recovery Concentration coronavirus COVID-19 disease Effect evaluate evidence of fertile Human men morphology no significant difference organs Oropharyngeal parameter Patient PCR test secreted Semen shown significantly lower specimen tested two groups Urine viability virus was done with COVID-19 [DOI] 10.1155/2022/6204880 PMC 바로가기
IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spikeArticle Published on 2022-09-052022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Adaptive immune response bind binding Cancer Cancer therapy cells cleavage cleave enzyme expressed expression facilitate homology identify IL4I1 immune immunosuppressive immunosuppressive enzymes Immunotherapy involved Lymphocytes mechanism of action monocyte Monocyte-derived macrophages moonlighting protein negative control Protease activity Protein Pseudotyped virus Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein secreted Spike. surface protein survival the spike protein TMPRSS13 TMPRSS2 transmembrane serine protease virus [DOI] 10.3389/fimmu.2022.982839 PMC 바로가기
Steric accessibility of the N-terminus improves the titer and quality of recombinant proteins secreted from Komagataella phaffiiArticle Published on 2022-09-052022-11-16 Journal: Microbial Cell Factories [Category] SARS, 변종, [키워드] addition addressed aggregation Alpha Amino acid applied benefit caused Cell cleavage cleave demonstrated eliminated extension extracellular space functional Golgi highest Host IMPROVE Modification N-terminal N-terminus observation occur peptide Pichia Pichia pastoris product Product quality protease Protein protein engineering protein sequence Proteins purification Receptor binding domain Recombinant protein recombinant proteins residue Saccharomyces cerevisiae secrete secreted secreted protein secretion signal signal peptide signal peptide. steric steric hindrance subunit the SARS-CoV-2 the signal peptide therapeutic vaccine antigen variant variants [DOI] 10.1186/s12934-022-01905-2 PMC 바로가기
Persistent Maintenance of Intermediate Memory B Cells Following SARS-CoV-2 Infection and Vaccination Recall ResponseSARS-CoV-2 감염 및 백신 회수 반응 이후 중간 기억 B 세포의 지속적인 유지Article Published on 2022-08-102022-09-12 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed antibodies antibody Antigen B cell B cell response booster CD21 CD27 CD4 CD4+ CD4+ T cell Cell correlated COVID-19 demonstrated determine elicited help highlight immune response Immunity immunization individual level infected individual Infection intermediate Kinetics Longevity longitudinal maintain maintenance memory B memory B cell memory B cells neutralization Neutralizing antibodies neutralizing antibody Pandemics persistence persistent phenotype Postinfection Protective Protein recall receptor recovered respond response SARS-CoV-2 SARS-COV-2 infection secreted significantly spike T cells the SARS-CoV-2 triggered vaccination vaccination. [DOI] 10.1128/jvi.00760-22 PMC 바로가기 [Article Type] Article
SARS-CoV-2-positive patients display considerable differences in proteome diversity in urine, nasopharyngeal, gargle solution and bronchoalveolar lavage fluid samplesSARS-CoV-2-양성 환자는 소변, 비인두, 양치액 및 기관지폐포 세척액 샘플에서 단백질체 다양성에 상당한 차이를 나타냅니다.Article Published on 2022-08-082022-09-11 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BALF Beijing Bronchoalveolar lavage fluid center chance change characterized Charle China collected coronavirus coronavirus 2 database demonstrated Department downloaded followed by gargle gargle solution Germany Human human body in urine individual infected with SARS-CoV-2 Infection information investigated Mayo Clinic Medicine nasopharyngeal nasopharyngeal sample Nasopharyngeal samples pathology peptide Protein Proteins proteome proteomic proteomics respiratory SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 virus SARS-CoV-2 viruses SARS-CoV-2-positive patient SARS-CoV-2-positive patients Science secreted seropositive individuals Severe acute respiratory syndrome significantly more solution status technology the SARS-CoV-2 virus UniProt unique university Urine USA virus viruses was used while [DOI] 10.1371/journal.pone.0271870 PMC 바로가기 [Article Type] Article
Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for COVID-19 PneumoniaClinical Trial Published on 2022-08-012022-10-05 Journal: Stem cell reviews and reports [Category] COVID19(2023년), SARS, 임상, [키워드] allergic allergic reaction Chinese clinical clinical study collected CORD COVID-19 COVID-19 pneumonia demonstrated duration of hospitalization effective Efficacy evaluated Exosome Exosomes Immunity induce Lung injury Mesenchymal stem cells mild case MSC MSCs nebulization nebulization. outcome Patient patients with COVID-19 Pneumonia promote pulmonary lesion purified reduce reducing registry Safe SARS-CoV-2 scientist secreted Seven STEM stem cell suggested therapeutic strategy therapy treated Treatment Trial was performed [DOI] 10.1007/s12015-022-10398-w PMC 바로가기 [Article Type] Clinical Trial